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1 Introduction Coronary heart disease (CHD) represents a significant threat to global health, characterized by complex and multifactorial pathogenesis ( The pathophysiological significance of ferroptosis in cardiovascular disease stems from its multifaceted involvement in abnormal iron metabolism, lipid peroxidation, and ROS accumulationprocesses fundamental to the development of coronary artery disease (CAD)

However, the existing body of research suggests that DSIP could be a promising tool in the treatment of sleep disorders, chronic pain, and neurodegenerative diseases.

These findings are in line with recent reports of sporadic MMNSTs retaining PRKAR1A expression and lacking metastatic potential

While the analogy isn't perfect, it captures the essence of why researchers often prefer localized protocols for joint-specific studies

SCFAs as epigenetic and metabolic modulators Gut microbiota metabolize dietary fibers into SCFAs, including acetate, propionate, and butyrate